Progesterone receptor antagonist ZK98299 analogues
1BygdemanM . S- ' ahnMLprogesteronereceptorblOCkageeffectonuntwinec mouth Ding Hacdl { tyandearlypregnancy . Cr . 1985.12 (1 ) : 452SchneiderMR . MiclmaH . NishinoY . . Tu II inhibit , insofZK12993 . Na shed 4o . . 1990.10 (3) : 6833 # instantaneous . He Changhai . New anti- early pregnancy turnip flail a bunch of non- heir to clinical application. Shanghai Shanghai pressure to shake the University Press , 1992.14P ~ gubalaJM. EagerWG . . PuffCP . Relativebindingaffini-tireofanl1prOB iliac [ insZK98299andZK98734forprog ~ - [ ET knock erecept ~ inIheendometriumandmyometriumofboa - netm keysJ collapse dread ship . J997, 7:9035 PuriCP. EagerWG . Pc ~ g . balaJM . ] z ~ duetionofmell ~ rlJa-tionbyan [ ipf0eZK98299incyclingbonnetmohy & handsome magic 4.1987.3S (4 ) : 4096N . efG, BelerS. EagerW . e /. News № withantipr gestationalandamiu ∞ ∞ f ' coactivities.SteP ,
UGG Online, M ~ , 1984.44 (4 ) l3497BelangerA.PhillbertD.TeutschG.Re0 such as dstereosp ~ cifIcsynthesisof children substitulu ~ 19norsteroi a trip basis .198 J.37 (4) : 3 619 Joan Guohong , Tu tree irrigation , Liao Qingjiang progesterone by the permanent antagonism Jing ZK98299 Taiwan into the seine Pharmaceutical go . .1992.23 ({ ) : 2099TortIliV.AIfortM.Teutr to G. . sr female n -resistant Na US4.634.695SynthesisofProgesteroneReceptorAntagonistZK98299 ' AnaloguesChenGuohua TuShuzi ,
ralph lauren polo, LiaoQingJiang'Re ~ ea'rchCenterofDrugs , m,
nike free run norge, hope m, the PMrmaveutivalU woman song ,
abercrombie france, N ∞ yoga 210009Inordertosearchfornovelprogesteronereceptorantagonistswithhighefficiencyandlowsideeffect of proge ~ terotxereceptorantagonistZK98299analogues ( 12) (13) andtheirCJrisomer (10) (11 ) weresynthesizedfrom3 +3 (1,2-ethanediyl-bisoxy) a 5a , 10a- epoxy a ... of a estraene a 17 one ( 1) viaafour_stepprocess . Thecompounds (S ~ 13) havenotbeenyetreportedintheliterature. Theirstrut-tureswereidentifiedbyUV + IR, MS, HNMR. Theefficienciesofthecompounds (10 ~ l3) onpgesteronereceptorwereunderinvestigation. KeywordsZK98299analogues; Progesteronereceptorantagonist; eJ3u-CH3steroids; Photochemicalepimerization
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